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Posts tagged ‘scientist’

COVID-19 — It’s Everywhere . . . Breakthrough in Basic Research May Defeat COVID-19

Breakthrough in Basic Research May Defeat COVID-19

by

Columbia University Professor Emeritus, Dr. David Figurski

presented by

Donna O’Donnell Figurski

 

(Disclaimer: The World Health Organization <WHO> has officially named the new coronavirus as SARS-CoV-2 and the disease it causes as COVID-19. Because the majority of people, including much of the press, commonly refers to the virus as “COVID-19,” to avoid confusion I use COVID-19 as the name of the virus in these posts.)

David H. Figurski, Ph.D & Survivor of Brain Injury

 

Exciting results indicate that a novel idea might bring COVID-19 under control.  The new technology has been shown to work at the lab bench.  Now scientists are doing animal studies and, later, human studies.

Scientists at Boston University (BU) and the University of California at San Diego (UCSD) have made coated nanoparticles that are covered with pieces of lung cell membrane. (About 1000 tiny particles, or “nanoparticles,” can line up in the space equal to the width of a human hair.) The coated nanoparticles mimic the lung cells that normally bind the virus and allow an infection to start.  But, when the virus tries to infect a coated nanoparticle, the virus dies.  Essentially, the coated nanoparticle is a lethal decoy.

Research in the lab indicates that the new technology might be able to end the COVID-19 pandemic. Also, if the technology works in humans, coated nanoparticles will likely be important for inactivating other viruses and for dealing with future pandemics.

Specific nanoparticles can be made to mimic any cell that any virus infects.  So, coated nanoparticles can be made that are specific for any virus (for example, for influenza virus or for Ebola virus).  Also, once the cell normally infected by a previously unknown virus to start an infection has been identified (as it was for COVID-19), the relevant coated nanoparticles can be made. So, a novel virus can be inactivated even though little is known about the molecular details of its biology.

Scientists were surprised to learn that the coated nanoparticles for COVID-19 bind the SARS-2 coronavirus even better than the lung cells normally infected by the virus.  So, this approach for COVID-19 is likely be very efficient.

In COVID-19 infections, sometimes the immune response is too active and causes severe disease or death.  The dexamethasone breakthrough I wrote about earlier works by dampening the immune response.  The scientists surprisingly found that coating another batch of nanoparticles with membrane pieces from cells of the immune system also dampened the immune response.

The scientists envision a protective coated nanoparticle mixture for COVID-19 that has two types of coated nanoparticles (one that mimics the lung cells that are infected and another that dampens the immune response). The mixture would be simply administered as a nasal spray.

 

Stay Safe and Healthy!

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(Photos compliments of contributor.)

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On the Air: . . . . . . . . . . . . . . . Guest: Dr. David Figurski

On the Air: Guest: Dr. David Figurski

presented by

Donna O’Donnell Figurski

David Figurski

David H. Figurski, Ph.D & Survivor of Brain Injury

 

Dr. David Figurski, retired professor of microbiology, talks about his brain injury and COVID-19

I don’t often publicize my radio show on the Brain Injury Radio Network, but one of our brain injury survivors is knowledgeable about the COVID-19 pandemic, which I’m sure is on your mind.  Like me, you probably have lots of questions.

My guest on the April 19th show was my husband, Dr. David Figurski.  David has been living with several physical disabilities since January 2005, when he had a brain hemorrhage, but, fortunately, after three brain surgeries in two weeks, he was unaffected cognitively.  For 35 years, including eight years after his traumatic brain injury, David was a professor in the Department of Microbiology & Immunology at Columbia University, where he also had a research lab.  David has done research on bacteria and viruses for 45 years.  Unsurprisingly, he has been very interested in the new human coronavirus and the global pandemic it has caused.news-clipart-news-anchor-4

My 80-minute show was live on April 19th, but it was recorded and can now be listened to at any time as a podcast.  My interview of David has two parts.  From 9:30 to 49:50, David and I talk about life with his brain injury.  From 49:50 to the end, David and I discuss the COVID-19 pandemic.

To Listen Go To:

SPEAK OUT! On the Air with . . . Brain Injury Radio Show Menu “Another Fork in the Road”

blogtalkradio.com/braininjuryradio/2020/04/20/another-fork-in-the-road-bi-survivorcolumbia-prof-dr-david-figurski-covid19

 

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(Photos compliments of guests.)

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Feel free to follow my blog. Click on “Follow” on the upper right sidebar.

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Sneak Peeks for Prisoners

My book, Prisoners without Bars: A Caregiver’s Tale, will be released to the public on November 1, 2018 by WriteLife Publishing of Boutique of Quality Books Publishing Company. Here are pre-order links for Barnes & Noble and Amazon.

 

Excerpt 1

Chapter 1

Everything’s Blurry

presented by

Donna O’Donnell Figurski

… On January 13, 2005, David’s morning started much the same as it did each day. The only difference was that he delayed his rising by one hour. He planned to work at home that morning, preparing a talk about his

figurski-1

David Figurski, PhD – a few months before brain injury

research that he expected to deliver at Wesleyan University in Connecticut on Saturday. A long-time professor-friend was retiring from the faculty, and David was a featured speaker at his retirement symposium. It was an invitation and an honor that may have saved David’s life. …

 

Please leave a comment/question. I will respond.

 

(Clip Art compliments of Bing.)

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