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SPEAK OUT! NewsBit . . . . . . Inosine Helps Brain-Injured Monkeys Recover Fine Motor Control

SPEAK OUT! NewsBit

Inosine Helps Brain-Injured Monkeys Recover Fine Motor Control

presented by

Donna O’Donnell Figurski

My husband, David, is a traumatic brain injury survivor since 2005. He is physically disabled as a result of his brain injury. As a molecular biologist from Columbia University, David is always searching for ways to improve his own life after his brain injury. He recently stumbled on this exciting research project, and we wanted to share this hopeful concept with others.

 

Disclaimer:

Neither David nor I is a medical doctor, and we are not suggesting any medical solutions. We are only publishing this article for your information.

 

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Inosine is a small molecule found in cells. Research with mice and rats has shown that inosine is released by stressed or damaged neurons. Inosine can turn on the genes for axon development. Axons are the long, threadlike membrane extensions needed for neurons to send an electrochemical message to other neurons. The new axons from undamaged neurons can rewire the brain (plasticity) to allow circuits to form that compensate for circuits lost from damage.

Adding inosine to neurons in culture stimulates the formation of more axons. Would inosine stimulate an increase in plasticity by increasing axon formation and thereby help recovery from brain injury? Consistent with this idea, neuroscientists found that rats recovered from brain injury better when inosine was present.pTqKnRpgc

Now neuroscientists at Boston University report testing inosine’s effect on a primate – the rhesus monkey. The study was small (8 monkeys) because monkey experiments are expensive, but, despite the small number, the results were significant. At the beginning, all 8 monkeys could easily grasp food treats with their dominant hand. The part of the brain needed for the required motor skills in the dominant hand was then deliberately damaged in each monkey. The 8 brain-injured monkeys were divided into two groups: 4 monkeys were treated by giving them inosine, and 4 were given a placebo. The researchers didn’t know which monkeys were getting inosine and which were getting the placebo.

After 14 weeks of treatment, the monkeys were examined for their ability to grasp a food treat. Three of the four inosine-treated monkeys grasped the food with their dominant hand normally. Fine motor control in the hand seemed to be the way it was prior to the brain injury. In contrast, the placebo-treated monkeys retrieved their food by using a compensatory strategy. The placebo-treated monkeys still had a problem with fine motor control in the hand.

mouse-hiThis preliminary study has extended evidence of the inosine benefit from mice and rats to a primate. The result indicates that inosine may one day benefit human victims of brain injury. Inosine is already in clinical trials for the treatment of multiple sclerosis and Parkinson’s Disease. Inosine appears to be safe – athletes have taken inosine supplements for decades.

Strictly speaking, this experiment addressed recovery of only a specific movement. The brain injuries were highly controlled – all were nearly identical, and they were in a specific area of the frontal lobe that affects fine motor control of the hand. Inosine experiments of this type have only been done in animal models. But even with all these caveats, there is reason to be optimistic. Inosine treatment may become a common human therapy for brain injury. Clearly more research is needed before inosine is shown to be useful in the clinic. (Full story)

 

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On The Air: Brain Injury Radio “Another Fork in the Road” with Author, Jim Proebstle

On The Air: Brain Injury Radio “Another Fork in the Road”

with

Author, Jim Proebstle

presented

by

Donna O’Donnell Figurski

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Jim Proebstle, author of “Unintended Impact: One Athlete’s Journey From Concussions in Amateur Football to CTE Dementia,” tells the story of his older brother, Dick Proebstle, who didn’t get the fame and fortune of some NFL Football players, but did get the repercussions as he received countless head injuries while playing high school and college football.

Dick’s life went from the stars to an abyss over the course of 50 years. He lost so much without his knowing or understanding why. In fact, his children and family didn’t understand his decline either. Jim Proebstle 1It wasn’t until CTE (Chronic Traumatic Encephalopathy) came to the forefront when neuropathologist, Dr. Bennet Omalu  discovered the disease in the autopsied brain of 50-year-old Mike Webster, a once-upon-a-time revered Pittsburgh Steeler whose life unexpectedly declined soon after retirement. This left Webster homeless and exhibiting abnormal behaviors. Soon after, the brains of many other deceased NFL players were examined and various degrees of (Chronic Traumatic Encephalopathy) were also found. Dr. Omalu’s discovery began to open eyes of many other scientists and Boston University began a study. 89 of the 93 donated NFL player brains, were found to have CTE, which explained to the families the many bizarre behaviors their loved ones were exhibiting before they died.

Jim Proebstle Unintended Impact BookJim wrote his book, “Unintended Impact” to not only honor his brother, but also to  raise awareness of the dangers of all head injuries. Jim also authored two other books, “Fatal Incident” and “In the Absence of Honor.” You can find any of Jims’ books at amazon.com

If you missed this show with Jim Proebstle, author of “Unintended Impact: One Athlete’s Journey from Concussions in Amateur Football to CTE Dementia” on “Another Fork in the Road” on March 20th, 2016, don’t fret. You can listen to the archived show here. Click the link below.

To learn more about Jim Proebstle, please visit his website.

See you “On the Air!”

On The Air: Brain Injury Radio “Another Fork in the Road” with author, Jim Proebstle

 

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SPEAK OUT! NewsBit . . . . . . U.S. Soccer Bans Heading for Players Age 10 and Under

U.S. Soccer Bans Heading for Players Age 10 and Under

presented

by

Donna O’Donnell Figurski

newsboy-thConcussions from playing soccer rank second to football in boys’ sports, but they are first in girls’ sports and second among all sports. Of the more than 3 million youths playing soccer in the U.S., 50,000 concussions were reported among high-school soccer players in 2010, more than the number from wrestling, basketball, baseball, and softball combined.  Parents and players brought a lawsuit accusing U.S. Soccer and other U.S. youth soccer organizations of negligence. As a result, U.S. Soccer established new rules that prevent heading by players age 10 and under and prohibits heading by 11- to 13-year-olds in practice. There are also new guidelines for soccer-trophy-clipart-soccer-team-clipartsoccer-team-with-trophy-clip-art-soccer-team-with-trophy-image-efwxwwe3substitution. For example, a player who replaces another player who has to leave the game because of a suspected concussion does not count as a substation.

U.S. Soccer governs only a fraction of youth soccer teams in the U.S., so they are recommending strongly that other leagues follow suit.  Dr. Cantu, a neurologist and a concussion specialist at Boston University, said that children’s brains are crucially developing and that the ages of 10 to 14 are especially critical in brain development. He also maintains that children’s neck muscles are not strong enough to support the head, making the risk of injury even greater. Safer Soccer, an organization that seeks a ban on 131181714310586452912266140-vector-illustration-for-a-anatomy-brain-in-separate-color-mdheading for players 14 and under, applauds the new rules. (The advisory board of Safer Soccer includes Brandi Chastain, Cindy Parlow Cone, and Joy Fawcett – former players of the women’s U.S. national soccer team, which has won four Olympic gold medals since 1996.) (Full story with video)

(Clip Art compliments of Bing.)

As I say after each post:

Please leave a comment by clicking the blue words “Leave a Comment” below this post.anim0014-1_e0-1

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No memory of the day that changed my life

My name is Michelle Munt and this is my story about surviving a brain injury and what I continue to learn about it. This is for other survivors and their loved ones, but also to raise awareness of what can happen to those in an accident. This invisible injury too often goes undiagnosed and it can be difficult to find information about it. I will talk about things that have helped me as I continue to recover and invite others to see if it works for them too.

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