TBI – Survivors, Caregivers, Family, and Friends

Posts tagged ‘research’

COVID-19 — It’s Everywhere . . . Progress in Controlling COVID-19

Progress in Controlling COVID-19


Columbia University Professor Emeritus, Dr. David Figurski

presented by

Donna O’Donnell Figurski


(Disclaimer: The World Health Organization <WHO> has officially named the new coronavirus as SARS-CoV-2 and the disease it causes as COVID-19. Because the majority of people, including much of the press, commonly refer to the virus as “COVID-19,” to avoid confusion I use COVID-19 as the name of the virus in these posts.)


David H. Figurski, Ph.D & Survivor of Brain Injury



I want to tell you about an amazing podcast, TWiV (This Week in Virology), created and hosted by Dr. Vincent Racaniello, a colleague of mine at Columbia University.

Vincent’s a virologist who has done cutting edge research on the molecular biology of influenza virus, poliovirus, and rhinoviruses (which cause the common cold). His podcasts feature several PhDs in microbiology (virologists, an immunologist, a parasitologist, and a science reporter who earned his PhD with Vincent) discussing the latest research and advances in viruses.

Vincent has been self-quarantining at home. Consequently, since March 13th, he has made more than 30 podcasts, nearly all concerning COVID-19, potential therapies and vaccines, and pandemics. His guests have been infectious disease scientists doing research or physicians in the trenches learning about the clinical manifestations of the virus and how to treat their patients.

Dr. Vincent Racaniello – Columbia University Virologist

Vincent’s podcasts are made for non-scientists to understand, but they are 1-2 hours long. Probably none of you has the time to listen that long. Therefore, I’m trying to listen to them so I can point you to episodes and minutes you may want to hear.

Podcast #622, released June 2, featured Dr. Emmie de Wit of the Rocky Mountain Labs in Montana. She’s a virologist doing drug and vaccine research in monkeys. Because Rocky Mountain Labs is one of the few places in the country with a high-safety-level facility, Dr. de Wit has worked with several dangerous viruses: SARS-1, MERS, pandemic influenza strains, and Ebola. Now she’s working with SARS-2.

I’ve boiled down Episode #622 to four segments totaling ~16 minutes.

  1. 26:05-26:35 – The spike protein of the virus coat initiates infection of a cell by attaching to the ACE2 protein (angiotensin converting enzyme 2) on the cell’s surface. Here Emmie tells how it took only days to identify ACE2 and confirm viral binding. Rich Condit, a virologist, was astonished by the speed. ACE2-binding by spike is a potential drug target.


  1. 37:15-39:44 – The PCR test (polymerase chain reaction), simple enough to be done on a large scale, detects the 30,000-nucleotide (or base) RNA chromosome of the virus. But, PCR is so sensitive that it can detect degradation fragments of the RNA, even though the person is no longer contagious. The only way to tell for sure is to detect viable virus in cell culture. This is hard to do and is only done in virology research labs. As a result, a person is considered infected and contagious if the PCR test is positive.

  1. 43:35-54:05 Remdesivir, an antiviral drug, is a nucleotide-analog that blocks the copying of the RNA chromosome to make more virus. Emmie showed that giving remdesivir to monkeys early (at 12-hours post infection) was very effective. But, humans don’t show symptoms for days, and, because remdesivir must be administered intravenously, patients are only given remdesivir if they are hospitalized. This is very late, and still there is a modest effect. Rich Condit talks about the possibility of producing an oral form of the drug. Then remdesivir could be taken earlier – maybe even at home – and might be very effective in humans.


  1. 58:25-60:40 This segment concerns a vaccine. (I’ll write more on this topic later, but you should know that there are three types of promising technologies: the viral protein-based, the viral gene-based, and the virus vector-based, in which a harmless virus carries a gene from a disease-producing virus for a protein that’s needed to infect cells.)2ff087415a5009984739aa8fde5d5d4a

Emmie tested a harmless chimpanzee adenovirus that was engineered to carry the COVID-19 spike gene. This adenovirus produces the coronavirus spike protein, needed for COVID-19 to infect cells. So, this harmless adenovirus should cause us to make antibodies that will block infection by COVID-19.

In Emmie’s experiment in monkeys, the vaccine worked so well that it allowed clinical trials to proceed in humans.

Stay Safe and Healthy!

Clip Art compliments of Bing.)

(Photos compliments of contributor.)

As I say after each post:

Please leave a comment by clicking the blue words “Leave a Comment” below this post.

Feel free to follow my blog. Click on “Follow” on the upper right sidebar.anim0014-1_e0-1

If you like my blog, share it intact with your friends. It’s easy! Click the “Share” buttons below.

SPEAK OUT! NewsBit . . . . . . . . Changing a Negative Feeling About a Memory

Changing a Negative Feeling About a Memory

newsboy-thThis is exciting, but complicated, basic research. Here I simplify the main experiments. Neuroscientists at the Massachusetts Institute of Technology (MIT) have identified a neuronal circuit in mice that associates a positive or negative feeling with a memory. In a tour de force of molecular studies of the brain, the researchers conducted experiments that provide considerable hope for future therapy in humans with syndromes like PTSD (post-traumatic stress disorder), anxiety, and depression. The scientists were able to turn a memory associated with a negative feeling into a memory that has a more positive feeling and vice versa.

(How relevant are studies done in mice? The mouse is an accepted animal model for humans. You might not expect it, but mice and humans are very similar genetically. The DNA sequences of the mouse and human chromosomes are known. Many mouse genes have sequences similar to human genes. They both code for proteins that have similar structures and do the same things. Because mouse and human genes are so similar, much of the underlying biology of mice and humans is also similar. Still there are differences. So until something has been shown to be true in humans, a scientist’s conclusions must be conservative. Most of the time, however, much is learned about humans from the mouse. It has become a convenient initial model for humans.)

The researchers at MIT engineered a virus that infects the mouse brain. They specifically infected either the hippocampus, the part of the brain that contains neurons that store contextual information about a memory (for example, the place), or the amygdala, the part of the brain that contains neurons that put a positive or negative emotional tag onto the memory. The engineered virus is essentially a dead-end. It doesn’t reproduce or harm the cell, but it does have an ability to cause infected neurons to make a light-sensitive protein – but only when the neuron is actively making a new memory. In this way, the researchers were able to make neurons involved in making a new memory sensitive to light. By implanting an optical fiber in the part of the brain that contained the light-sensitive neurons (i.e., in the hippocampus or in the amygdala), the scientists could use light to turn on these memory-making neurons at will. The general technique of using a light-sensitive protein to activate a cell is called “optogenetics.” When the light-sensitive neurons are activated by the researcher, the mice recall that memory with its associated positive or negative feeling. To make a memory with a positive feeling, male mice were allowed to mix with female mice. To make a memory having an associated negative feeling, mice were put into a special cage and given a mild electrical shock. For both kinds of memories, the neurons involved could be turned on by light.

The researchers then took the mice and put them into a cage with two compartments. When a mouse with a negative memory explored a particular compartment, the researchers turned on its bad-memory neurons by shining a laser into the optical fiber to activate those neurons. The mice “remembered” the bad feeling and avoided that compartment. When the experiment was done with the mice having a good memory, the mice preferred that compartment. These results were seen only when neurons of the hippocampus were activated. No change in mouse behavior was seen when amygdala neurons were activated. Whereas the amygdala is needed to add the positive or negative feeling to a memory, the researchers concluded that a memory with its associated feeling is stored in the hippocampus.

The researchers then asked if they could change a negative memory into a positive memory and vice versa. They took the male mice with the negative memory and mixed them with females to make a positive memory. When they used light to activate the bad-memory neurons, the positive feeling from mixing them with females dominated. Unexpectedly, those mice did not suddenly avoid the females when the researchers activated the bad-memory neurons. When the mice were put back into the cage with two compartments, they went randomly into both compartments, even when the researchers activated the bad-memory neurons with light. The bad memory was no longer causing them to avoid one of the compartments. The negative tag had been supplanted by the positive feeling. What happened to the first (negative) tag? Was it removed? Was it changed? This question is being investigated. When the experiment was reversed, the scientists found that the positive feeling became more negative.

This new research gives a molecular explanation for why emotion associated with a memory can be changed – the basis of current therapy. Dr. Susumu Tonegawa, who directed the research, believes that the amygdala has two kinds of neurons: neurons that can tag a memory with a positive feeling and other neurons that can tag a memory with a negative feeling. He wants to identify those two populations of cells and understand how they work at the molecular level. Such information will be valuable for the development of new therapies and drugs. (Full story)

(Clip Art compliments of Bing.)

Tag Cloud


Help One Person Excel - To Be Independent

  WriteForKids - Writing Children's Books

Become a published children's book author via books, ebooks and apps.

For the Love of Books, Old and New

Katie Fischer, Writer and Reader of Stories

Charlie Bown

Children's Author

Jessica Hinrichs

“We write to taste life twice, in the moment and in retrospect.” ― Anais Nin

VIVIAN KIRKFIELD - Writer for Children

Picture Books Help Kids Soar

Mindy’s Writing Wonderland

For authors, parents, teachers & everyone who loves children’s books.

Math is Everywhere

Where the magic of math and writing comes together!

Surviving Traumatic Brain Injury

TBI - Survivors, Caregivers, Family, and Friends

How Life Has Happened For Me

Grow Through What You Go Through

Claire Stibbe

Thriller Author and Blogger


New Age Blogger

The Care Factor

Loving someone with a Traumatic Brain Injury

Montclair Write Group

Writing Support Group

Brain Injury Support Group of Duluth-Extension

Brain Injury Information and SUPPORT

Women Worldwide Network

Women around the world share their incredible stories

Brain Aneurysm Global Insight

Brain Aneurysm, cerebral hemorrhaging, hemorrhage stroke

%d bloggers like this: